High frequency of autonomous T-cell proliferation compatible with T-cell large granular lymphocytic leukemia in patients with cytopenia of unknown etiology

Bektas Ö., ÜNER A., Aydin S. M., Eliacik E., Uz B., Isik A., ...More

INTERNATIONAL JOURNAL OF HEMATOLOGY, vol.102, no.2, pp.211-217, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 102 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1007/s12185-015-1816-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.211-217
  • Keywords: Large granular lymphocyte leukemia, Idiopathic cytopenia of undetermined significance, Anemia, Thrombocytopenia, Neutropenia, Cytopenia, LYMPHOPROLIFERATIVE DISEASE, PATHOGENESIS, EXPANSIONS, REPERTOIRE, CLONALITY
  • Karadeniz Technical University Affiliated: No


Large granular lymphocytic leukemia/lymphoproliferative disorder (LGL-L/LPD) is a heterogeneous neoplastic disease of large granular lymphocytes and is a well-known cause of cytopenias. We aimed to reveal the incidence of LGL-L/LPD in patients with cytopenia(s) of unknown etiology (CUE). Twenty-eight patients with CUE were investigated for LGL-L/LPD. T-cell LGL leukemia (LGL-L) was diagnosed in 12 (42.9 %) patients. The frequencies of LGL-L in patients who had anemia, neutropenia, and thrombocytopenia were 9/14 (64.2 %), 11/23 (47.8 %), and 3/10 (30 %), respectively. Seventeen of the 28 patients met the criteria of idiopathic cytopenia of undetermined significance (ICUS), and LGL-L was found in six (35.3 %) of them. We conclude that LGL-L is a rather common disease in patients with CUE and ICUS. It should be considered in this patient group and investigated thoroughly.