LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.7, pp.706-712, 2018 (SCI-Expanded)
Background: Schiff bases have a broad spectrum of biological activities including antiviral, antibacterial, antifungal, antimalarial, anti-inflammatory antiproliferative and antipyretic properties. 1,3,4-oxadiazoles have been reported to show spectrum of biological activities including such as antiviral, fungicidal, antineoplastic, antimicrobial anti-HIV, antitubercular, antihypoglycemic, antimalarial, antioxidant, analgesic, anti-inflammatory, anticonvulsant, anticancer and inhibition of tyrosinase, antitumor and antiproliferative. Morpholine is known as a valuable structure for the synthesis of more efficacious antimicrobial agents. Therefore, the study presents the synthesis, antimicrobial and antioxidant evaluation of a series of 1,3,4 substituted oxadiazole derivatives