Synthesis and Biological Activity of New Schiff Bases of Benzylideneamine Bearing Thiophene, 1,2,4-triazolone, 1,3,4-oxadiazole, Morpholine Moieties


ÜNVER Y. , Bektas E.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.7, pp.706-712, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.2174/1570180814666171012163651
  • Title of Journal : LETTERS IN DRUG DESIGN & DISCOVERY
  • Page Numbers: pp.706-712

Abstract

Background: Schiff bases have a broad spectrum of biological activities including antiviral, antibacterial, antifungal, antimalarial, anti-inflammatory antiproliferative and antipyretic properties. 1,3,4-oxadiazoles have been reported to show spectrum of biological activities including such as antiviral, fungicidal, antineoplastic, antimicrobial anti-HIV, antitubercular, antihypoglycemic, antimalarial, antioxidant, analgesic, anti-inflammatory, anticonvulsant, anticancer and inhibition of tyrosinase, antitumor and antiproliferative. Morpholine is known as a valuable structure for the synthesis of more efficacious antimicrobial agents. Therefore, the study presents the synthesis, antimicrobial and antioxidant evaluation of a series of 1,3,4 substituted oxadiazole derivatives