Synthesis and Biological Activity of New Schiff Bases of Benzylideneamine Bearing Thiophene, 1,2,4-triazolone, 1,3,4-oxadiazole, Morpholine Moieties

ÜNVER Y., Bektas E.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.7, ss.706-712, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 7
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570180814666171012163651
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.706-712
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background: Schiff bases have a broad spectrum of biological activities including antiviral, antibacterial, antifungal, antimalarial, anti-inflammatory antiproliferative and antipyretic properties. 1,3,4-oxadiazoles have been reported to show spectrum of biological activities including such as antiviral, fungicidal, antineoplastic, antimicrobial anti-HIV, antitubercular, antihypoglycemic, antimalarial, antioxidant, analgesic, anti-inflammatory, anticonvulsant, anticancer and inhibition of tyrosinase, antitumor and antiproliferative. Morpholine is known as a valuable structure for the synthesis of more efficacious antimicrobial agents. Therefore, the study presents the synthesis, antimicrobial and antioxidant evaluation of a series of 1,3,4 substituted oxadiazole derivatives