Akademik Veri Yönetim Sistemi
The 10th International Mediterranean Symposium on Medicinal and Aromatic Plants, İstanbul, Türkiye, 25 - 27 Nisan 2024, ss.131
Hedera helix L. and Hedera colchica K. Koch are commonly used as painkillers and for bronchitis, whooping cough, arthritis, and rheumatism [1,2]. The medicinal effects of H. helix on cough and bronchitis have been proven and its use in the treatment of mild inflammatory conditions of the mucous membranes of the upper respiratory tract and chronic inflammatory bronchial diseases has been approved by the German E Commission [3]. Due to these effects, standardised dry extracts obtained from the leaves of H. helix are used as pharmaceutical raw materials in mono products as well as in combined products developed by different companies [2]. In our study, it aims to evaluate to antiinflammatory activities of H. helix and H. colchica species in two different vegetation periods, obtained extracts rich in saponin and phenolic substances. Compared to H. helix, H. colchica has a higher total phenolic and total saponin content. H. colchica fruit extract (C3S), with the highest saponin content (468.19 ± 16.01 mg HE/g dry weight), and H. colchica early vegetative stage leaf extract (C1F), with the highest total phenolic content (108.60 ± 5.61 mg GAE/g dry weight) were tested for antiinflammatory effects via COX-1 and COX-2. According to the results, C1F showed the highest selective COX-2 inhibition. The experimental results show that besides saponins, various secondary metabolites present in Hedera species may also contribute to the efficacy of the extract; by using appropriate extraction techniques, more potent raw materials can be provided to the market. Key Words: antiinflammatory, Hedera helix, Hedera colchica, medicinal product