Akademik Veri Yönetim Sistemi
IRANIAN RED CRESCENT MEDICAL JOURNAL, cilt.27, sa.1, 2025 (SCI-Expanded)
Background and Objectives: Acute appendicitis is one of the most widespread causes of acute abdomen and one of the most common indications for abdominal surgery worldwide. This study was performed to examine the practicability of laboratory data in differentiating complicated appendicitis (CA) and uncomplicated appendicitis (UA) in different age groups and to investigate age-related differences such as histopathological diagnosis, mortality, intensive care unit (ICU) admission, and length of hospital stay.
Methods: In this retrospective study, 785 patients over the age of two with a preliminary diagnosis of acute appendicitis were included over a five-year study period. Positive appendectomy patients identified as a result of pathological examinations were divided into two subgroups, CA and UA. The patients were also divided into groups based on their age at the time of presentation to the emergency department: 2-17 years (Group A), 18-64 years (Group B), and 65 years and older (Group C).
Results: White blood cell (WBC), neutrophil, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-white blood cell ratio (NWR), C-reactive protein (CRP), alanine aminotransferase (ALT), and direct bilirubin values, as well as the length of hospitalization, were all greater in the CA group compared to the UA group, while lymphocyte values were lower. All the differences were statistically significant (For NLR,NWR, CRP,length of hospitalization P<0.001; for WBC, neutrophil, PLR, ALT, direct bilirubin values and lymphocyte P<0.05). There was no difference between the pediatric patients and those in the 18-64 age group in terms of length of hospitalization, ICU admission, or mortality.
Conclusion: NLR and PLR calculation is an easily available, simple, and low-cost method for estimating the probability of complications in the early period in patients with appendicitis.