Akademik Veri Yönetim Sistemi
Cukurova Medical Journal, cilt.46, 2021 (ESCI)
Meningiomas are the most common primary intracranial
tumor thought to derived from arachnoidal cap cells in the
meningeal coverings of the spinal cord and brain. The
current WHO classification, published in 2016, includes
nine different subtypes of grade 1 meningiomas, three
different subtypes of grade 2 meningiomas, and three
different subtypes of grade 3 meningiomas. Metaplastic
meningioma is a rare variant which shows focal or diffuse
mesenchymal tissue component. Xanthomatous
meningioma which has foamy cell changes is a quite rare
variant of metaplastic meningioma. Two patients, 54 and
59 years old, who applied to our clinic with similar
symptoms, were operated for meningioma.
Histopathological examination of their biopsy showed that
neoplastic cells had oval-round nuclei and eosinophilic
cytoplasm. In xanthomatous meningioma, some
neoplastic cells had clear vacuolated cytoplasm (foamy
cells). In microscopic examination of resection material in
one of these patients, cells in some areas of the tumor had
clear vacuolated cytoplasm (foamy cells). These neoplastic
cells were scattered among other meningothelial cells and
they were positive for EMA. To the best of our knowledge,
until today there have been only 14 reported xanthomatous
meningioma cases in English literature. Here, we aimed to
discuss the pathogenesis and differential diagnosis of
xanthomatous meningioma in two different cases.