Clinical and therapeutic predictors of disease outcomes in AQP4-IgG + neuromyelitis optica spectrum disorder

Kunchok, Amy; Malpas, Charles; Nytrova, Petra; Havrdova, Eva; Alroughani, Raed; TERZİ, MURAT; Yamout, Bassem; Hor, Jyh; KARABUDAK, RANA; BOZ, CAVİT; ÖZAKBAŞ, SERKAN; Olascoaga, Javier; Simo, Magdolna; Granella, Franco; Patti, Francesco; McCombe, Pamela; Csepany, Tunde; Singhal, Bhim; Bergamaschi, Roberto; Fragoso, Yara; Al-Harbi, Talal; Turkoglu, Recai; Lechner-Scott, Jeannette; Laureys, Guy; Oreja-Guevara, Celia; Pucci, Eugenio; Sola, Patrizia; Ferraro, Diana; Altintas, Ayse; Soysala, Aysun; Vucic, Steve; Grand'Maison, Francois; Izquierdo, Guillermo; Eichau, Sara; Lugaresi, Alessandra; Onofrj, Marco; Trojano, Maria; Marriott, Mark; Butzkueven, Helmut; Kister, Ilya; Kalincik, Tomas

doi:10.1016/j.msard.2019.101868

Clinical and therapeutic predictors of disease outcomes in AQP4-IgG + neuromyelitis optica spectrum disorder

Kunchok A., Malpas C., Nytrova P., Havrdova E. K., Alroughani R., TERZİ M., ...More

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.38, 2020 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 38
Publication Date: 2020
Doi Number: 10.1016/j.msard.2019.101868
Journal Name: MULTIPLE SCLEROSIS AND RELATED DISORDERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
Keywords: Neuromyelitis optica spectrum disorder, Therapy, Predictors, Relapses, Disability, Immunosuppression, OPTICA SPECTRUM DISORDER, NEUROMYELITIS-OPTICA, MULTIPLE-SCLEROSIS, CHINESE PATIENTS, AZATHIOPRINE, RITUXIMAB, EFFICACY, REGISTRY
Karadeniz Technical University Affiliated: Yes

Abstract

Background: Aquaporin-4-IgG positive (AQP4-IgG(+)) Neuromyelitis Optica Spectrum Disorder (NMOSD) is an uncommon central nervous system autoimmune disorder. Disease outcomes in AQP4-IgG + NMOSD are typically measured by relapse rate and disability. Using the MSBase, a multi-centre international registry, we aimed to examine the impact immunosuppressive therapies and patient characteristics as predictors of disease outcome measures in AQP4-IgG + NMOSD.