Evaluation of Prognostic Factors and Survival Results in Pediatric Hodgkin’s Lymphoma-single center experience from Eastern Black Sea Region of Turkey

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Kandaz M., Güler O. C., Memiş Y., Bahat Z., Canyılmaz E., Yöney A.

Journal of Hematology and Blood Disorders, cilt.3, sa.1, ss.1-5, 2017 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 1
  • Basım Tarihi: 2017
  • Dergi Adı: Journal of Hematology and Blood Disorders
  • Derginin Tarandığı İndeksler: Other Indexes
  • Sayfa Sayıları: ss.1-5
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: Study clinical features and treatment results of Pediatric Hodgkin's Lymphoma patients and investigate prognostic factors affecting survival.

Materials and Methods: Data of 44 Hodgkin's Lymphoma patients (15 females, 29 males) below 16 years of age [mean age 10.4 ± 4.2 (3-16)] treated and monitored in our institution between 1996 and 2015 was studied retrospectively.

Results: 50% of the patients had early stage (stage I-II) of the disease. The most common histological type was mixed cellular Hodgkin's lymphoma (MCHL). All patients received chemotherapy. After chemotherapy, involved field radiotherapy was administered to all patients. Median survival time was 164.32±13.8 months and 1-, 3-, 5- and 10-year survival rates were 96%, 91.8%, 88.3% and %87.9, respectively. In univariate analysis, stage (p<0.005) and ECOG performance score (p<0.0001) were found to be variables with effects on overall survival. In multivariate analysis, only ECOG performance score (p<0.003) was found to be statistically significant.

Conclusion: Although our treatment results are similar to those of other treatment centers, we will be able to contribute more to clinical features and treatment results of pediatric Hodgkin's lymphoma patients, with higher number of patients.

Keywords: Pediatric Hodgkin's lymphoma; Patient’s characteristics; Chemotherapy; Radiotherapy; Prognostic factors; Survival