In vitro cholinesterases, tyrosinase, α-glucosidase inhibitory and anticancer effects of novel silicon phthalocyanines containing geraniol/phytol

Yalazan H., BARUT B., YALÇIN C. Ö., KANTEKİN H., YILDIRMIŞ S.

INORGANIC CHEMISTRY COMMUNICATIONS, cilt.165, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 165
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.inoche.2024.112548
  • Dergi Adı: INORGANIC CHEMISTRY COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, DIALNET
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The axially silicon phthalocyanines, consisting of different acyclic hydrocarbons, were generated by SiPcCl 2 reacting with either geraniol or phytol in toluene in the presence of NaH. FT-IR, UV-Vis, MALDI TOF, and NMR spectroscopy all provided information about the structures of silicon phthalocyanines. The cholinesterase, tyrosinase, and alpha-glucosidase inhibitory effects of G-SiPc and P-SiPc were tested using spectrophotometric assays. The IC 50 values of G-SiPc and P-SiPc were 7.22 +/- 0.53 and 11.28 +/- 2.73 mu M for AChE; 70.05 +/- 3.00 and 60.55 +/- 3.80 mu M for BuChE. In addition, G-SiPc and P-SiPc inhibited the tyrosinase enzyme with IC 50 values of 280.36 +/- 7.92 mu M and 40.51 +/- 3.88 mu M, respectively. P-SiPc had about seven times stronger inhibitory properties than G-SiPc . The substances exhibited less inhibition than acarbose in the alpha-glucosidase inhibitory assay. Finally, the cytotoxic effects of G-SiPc and P-SiPc were investigated using the MTT assay on L-929 mouse fibroblast cells as normal cells. G-SiPc and P-SiPc did not reach IC 50 values up to 100 mu M.