Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

YALDIZ ÇOBANOĞLU, HATİCE; Vuralkan, Erkan; ARSLAN, ABDULLAH; Mirasoglu, Bengusu; Toklu, A.

doi:10.21053/ceo.2017.01704

Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

YALDIZ ÇOBANOĞLU H. B., Vuralkan E., ARSLAN A., Mirasoglu B., Toklu A. S.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, vol.12, no.1, pp.66-71, 2019 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 12 Issue: 1
Publication Date: 2019
Doi Number: 10.21053/ceo.2017.01704
Journal Name: CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.66-71
Keywords: Hyperbaric Oxygen, Cisplatin, Ototoxicity, Rats
Open Archive Collection: AVESIS Open Access Collection
Karadeniz Technical University Affiliated: Yes

Abstract

Objectives. Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats.