Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

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YALDIZ ÇOBANOĞLU H. B., Vuralkan E., ARSLAN A., Mirasoglu B., Toklu A. S.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, vol.12, no.1, pp.66-71, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.21053/ceo.2017.01704
  • Journal Name: CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.66-71
  • Keywords: Hyperbaric Oxygen, Cisplatin, Ototoxicity, Rats
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objectives. Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats.