Paraneoplastic Peripheral Neuropathy Preceding the Diagnosis of Hodgkin's Lymphoma: Differential Diagnosis

Kavgaci H., SÖNMEZ M., Cobanoglu U., ALİOĞLU Z., YILDIZ B., ÖZDEMİR F., ...More

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.29, no.5, pp.1342-1345, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2009
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1342-1345
  • Karadeniz Technical University Affiliated: Yes


A 30-year-old male patient presented with symptoms of peripheral neuropathy (PN). A work-up at that time failed to reveal an underlying disease. The patient received gabapentin for two months with no improvement and intravenous immunoglobulin (IVIG) was initiated subsequently. After sixteen months of IVIG therapy, lymphadenopathy and splenomegaly were detected. Diagnosis was Hodgkin's lymphoma (HL). Complete remission was observed with systemic polychemotherapy; however, HL relapsed one year later. High dose chemotherapy with autologous stem cell transplantation was performed and complete remission of HL was achieved during which PN also improved. Patients with unexplained PN should be evaluated for the presence of HL.