Voltammetric Determination of Nimesulide Using Multiwalled Carbon Nanotubes Modified Carbon Paste Electrode

AĞIN F., SERDAROĞLU V.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.13, no.3, pp.335-341, 2016 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.4274/tjps.2016.09
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.335-341
  • Keywords: Karbon pasta elektrot, Tayin, Cok duvarli karbon nanotup, Nimesulid, Voltametri, ACETYLCHOLINESTERASE, PK(A), SERUM
  • Karadeniz Technical University Affiliated: Yes

Abstract

A multiwalled carbon nanotubes (MWCNTs) modified carbon paste electrode (CPE) was prepared for voltammetric determination of anti-inflammatory drug nimesulide (NIM). The electro-oxidation of NIM was exhibited irreversible and diffusion controlled process with MWCNTs modified CPE. The linear response between peak current and concentration in the quantitative determination of NIM by differential pulse voltammetry in 0.1 M phosphate buffer solution (PBS) at pH 5.0 obtained in the range of the concentration from 6x10(-8)-1x10(-5) M with limit of detection (LOD) 1.07x10(-9) M and limit of quantification (LOQ) 3.24x10(-9) M. Differential pulse voltammetry was developed according to linear response of NIM with high selectivity, precision, accuracy using modified electrode was successfully applied to the determination of NIM in pharmaceuticals and human serum samples.