Synthesis and Biological Significances of New Heterocyclic Compounds Containing 5-(4-Chlorobenzyl)-3-(4-Chlorophenyl)-1H-1,2,4-triazol Ring

Ozdemir Y., Gultekin E., BEKİRCAN O.

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, cilt.39, sa.6, ss.1055-1067, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 6
  • Basım Tarihi: 2017
  • Dergi Adı: JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1055-1067
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, some novel 5-(4-chlorobenzyl)-3-(4-chlorophenyl)-1H-1,2,4-triazol derivatives were synthesized starting from 4-amino-3-(4-chlorobenzyl)-5-(4- chlorophenyl)-4H-1,2,4- triazole (1). The structures of the synthesized compounds were clarified using IR, H-1 NMR, C-13 NMR, elemental analyses and mass spectral techniques. The synthesized compounds were tested for antimicrobial and anti-lipase inhibitory activities. Among the tested substances, compounds 3, 8c, 8d, 8e and 9d exhibited good activity against Gram-positive bacteria. Furthermore, all the synthesized compounds were investigated with regard to pancreatic lipase inhibition activity, and compounds 5e, 8b, and 9b showed a considerable anti-lipase activity at various concentrations.