The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude

LECHNER-SCOTT J., SPENCER B., DE MALMANCHE T., Attia J., Fitzgerald M., TROJANO M., ...Daha Fazla

MULTIPLE SCLEROSIS JOURNAL, cilt.18, sa.7, ss.974-982, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/1352458511431729
  • Dergi Adı: MULTIPLE SCLEROSIS JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.974-982
  • Anahtar Kelimeler: multiple sclerosis, oligoclonal bands, latitude, data base, prognosis, progression 2, CEREBROSPINAL-FLUID, CLINICAL-FEATURES, DIAGNOSTIC-CRITERIA, IGG BANDS, DISABILITY, ASSOCIATION, PROGRESSION, RELEVANCE, DISEASE, MS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: With the advent of MRI scanning, the value of lumbar puncture to assess oligoclonal band (OCB) status-for the diagnosis of multiple sclerosis (MS) is increasingly uncertain. One major issue is that the reported frequency of cerebrospinal fluid (CSF)-restricted oligoclonal banding for the diagnosis of MS varies considerably in different studies. In addition, the relationship between OCB positivity and disease outcome remains uncertain, as reported studies are generally too small to assess comparative disability outcomes with sufficient power.