The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude

LECHNER-SCOTT J., SPENCER B., DE MALMANCHE T., Attia J., Fitzgerald M., TROJANO M., ...Daha Fazla

MULTIPLE SCLEROSIS JOURNAL, cilt.18, ss.974-982, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/1352458511431729
  • Sayfa Sayıları: ss.974-982


Background: With the advent of MRI scanning, the value of lumbar puncture to assess oligoclonal band (OCB) status-for the diagnosis of multiple sclerosis (MS) is increasingly uncertain. One major issue is that the reported frequency of cerebrospinal fluid (CSF)-restricted oligoclonal banding for the diagnosis of MS varies considerably in different studies. In addition, the relationship between OCB positivity and disease outcome remains uncertain, as reported studies are generally too small to assess comparative disability outcomes with sufficient power.