MULTIPLE SCLEROSIS JOURNAL, vol.18, no.7, pp.974-982, 2012 (SCI-Expanded)
Article / Article
MULTIPLE SCLEROSIS JOURNAL
Science Citation Index Expanded (SCI-EXPANDED), Scopus
multiple sclerosis, oligoclonal bands, latitude, data base, prognosis, progression 2, CEREBROSPINAL-FLUID, CLINICAL-FEATURES, DIAGNOSTIC-CRITERIA, IGG BANDS, DISABILITY, ASSOCIATION, PROGRESSION, RELEVANCE, DISEASE, MS
Karadeniz Technical University Affiliated:
Background: With the advent of MRI scanning, the value of lumbar puncture to assess oligoclonal band (OCB) status-for the diagnosis of multiple sclerosis (MS) is increasingly uncertain. One major issue is that the reported frequency of cerebrospinal fluid (CSF)-restricted oligoclonal banding for the diagnosis of MS varies considerably in different studies. In addition, the relationship between OCB positivity and disease outcome remains uncertain, as reported studies are generally too small to assess comparative disability outcomes with sufficient power.