The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude


LECHNER-SCOTT J., SPENCER B., DE MALMANCHE T., Attia J., Fitzgerald M., TROJANO M., ...More

MULTIPLE SCLEROSIS JOURNAL, vol.18, no.7, pp.974-982, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 7
  • Publication Date: 2012
  • Doi Number: 10.1177/1352458511431729
  • Title of Journal : MULTIPLE SCLEROSIS JOURNAL
  • Page Numbers: pp.974-982
  • Keywords: multiple sclerosis, oligoclonal bands, latitude, data base, prognosis, progression 2, CEREBROSPINAL-FLUID, CLINICAL-FEATURES, DIAGNOSTIC-CRITERIA, IGG BANDS, DISABILITY, ASSOCIATION, PROGRESSION, RELEVANCE, DISEASE, MS

Abstract

Background: With the advent of MRI scanning, the value of lumbar puncture to assess oligoclonal band (OCB) status-for the diagnosis of multiple sclerosis (MS) is increasingly uncertain. One major issue is that the reported frequency of cerebrospinal fluid (CSF)-restricted oligoclonal banding for the diagnosis of MS varies considerably in different studies. In addition, the relationship between OCB positivity and disease outcome remains uncertain, as reported studies are generally too small to assess comparative disability outcomes with sufficient power.