7,8-Dihydroxyflavone alleviates Endoplasmic Reticulum Stress in cafeteria diet-induced metabolic syndrome

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Sahin E., Saglam N., Erdem Ş., Alvuroglu E., Abidin İ., Yulug E., ...Daha Fazla

LIFE SCIENCES, cilt.306, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 306
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.lfs.2022.120781
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Insulin resistance, Liver, Pancreas, Inflammation, BDNF, UNFOLDED PROTEIN RESPONSE, OXIDATIVE STRESS, NEUROTROPHIC FACTOR, INDUCED OBESITY, ADIPOCYTE DIFFERENTIATION, ANTIOXIDANT ACTIVITY, INFLAMMATION, ACTIVATION, MODEL, TRKB
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Aims: Prolonged Endoplasmic Reticulum Stress (ERS) is involved in the pathogenesis of metabolic syndrome, including type-2 diabetes mellitus, cardiovascular diseases, atherosclerosis, obesity, and fatty liver disease. There have been significant efforts to discover molecules to treat ERS and/or to ameliorate associate symptoms. In this study, we investigated the effect of 7,8-Dihydroxyflavone (7,8-DHF) on ERS in liver and pancreas tissues in a cafeteria (CAF) diet induced metabolic syndrome model.