7,8-Dihydroxyflavone alleviates Endoplasmic Reticulum Stress in cafeteria diet-induced metabolic syndrome


Creative Commons License

Sahin E., Saglam N., Erdem S., Alvuroglu E., Abidin İ., Yulug E., ...More

LIFE SCIENCES, vol.306, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 306
  • Publication Date: 2022
  • Doi Number: 10.1016/j.lfs.2022.120781
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Insulin resistance, Liver, Pancreas, Inflammation, BDNF, UNFOLDED PROTEIN RESPONSE, OXIDATIVE STRESS, NEUROTROPHIC FACTOR, INDUCED OBESITY, ADIPOCYTE DIFFERENTIATION, ANTIOXIDANT ACTIVITY, INFLAMMATION, ACTIVATION, MODEL, TRKB
  • Karadeniz Technical University Affiliated: Yes

Abstract

Aims: Prolonged Endoplasmic Reticulum Stress (ERS) is involved in the pathogenesis of metabolic syndrome, including type-2 diabetes mellitus, cardiovascular diseases, atherosclerosis, obesity, and fatty liver disease. There have been significant efforts to discover molecules to treat ERS and/or to ameliorate associate symptoms. In this study, we investigated the effect of 7,8-Dihydroxyflavone (7,8-DHF) on ERS in liver and pancreas tissues in a cafeteria (CAF) diet induced metabolic syndrome model.