Augmented mitochondrial cytochrome c oxidase activity in children with iron deficiency: a tandem between iron and copper?

Bahadır A., Erduran E., Değer O., Birinci Y., Ayar A.

ARCHIVES OF MEDICAL SCIENCE, vol.14, no.1, pp.151-156, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.5114/aoms.2016.59602
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.151-156
  • Karadeniz Technical University Affiliated: Yes

Abstract

Introduction: Dyshomeostasis of essential trace elements including iron and copper plays a key role in the pathogenesis of a myriad of serious conditions including iron deficiency (ID) anemia, in which impaired cellular energy metabolism is prominent. Although experimental studies documented decreased activity of cytochrome c oxidase (CytOx) in ID, there are not enough clinical data. The present study was conducted to determine serum copper levels and activity of mitochondrial CytOx in isolated lymphocytes of patients with iron deficiency.