Synthesis of novel monostyryl and distyryl boron dipyrromethenes bearing 4-((2-hydroxyethyl)(methyl)amino group as cholinesterase and tyrosinase inhibitors


Arslan T., KELES T. , Barut B. , ÖZEL A. , BIYIKLIOĞLU Z.

INORGANICA CHIMICA ACTA, vol.471, pp.121-125, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 471
  • Publication Date: 2018
  • Doi Number: 10.1016/j.ica.2017.10.020
  • Title of Journal : INORGANICA CHIMICA ACTA
  • Page Numbers: pp.121-125

Abstract

In this study, the synthesis of novel Monostyryl and Distyryl boron dipyrromethene dyes containing 4-((2-hydroxyethyl)(methyl)amino) group to determine neuroprotective potential has been reported for the first time. They were synthesized starting from BODIPY dye 1. Their inhibitory properties against Acetylcholinesterase/Butyrylcholinesterase (AChE/BuChE) and tyrosinase (Tyr) were evaluated according to Ingkaninan's and Masuda's methods and kinetic analysis of compounds was done using LineweaverBurk and Dixon plots. (C) 2017 Elsevier B.V. All rights reserved.