Synthesis of novel monostyryl and distyryl boron dipyrromethenes bearing 4-((2-hydroxyethyl)(methyl)amino group as cholinesterase and tyrosinase inhibitors

Arslan, Tayfun; KELES, TURGUT; Barut, BURAK; ÖZEL, ARZU; BIYIKLIOĞLU, ZEKERİYA

doi:10.1016/j.ica.2017.10.020

Synthesis of novel monostyryl and distyryl boron dipyrromethenes bearing 4-((2-hydroxyethyl)(methyl)amino group as cholinesterase and tyrosinase inhibitors

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Arslan T., KELES T., Barut B., ÖZEL A., BIYIKLIOĞLU Z.

INORGANICA CHIMICA ACTA, vol.471, pp.121-125, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 471
Publication Date: 2018
Doi Number: 10.1016/j.ica.2017.10.020
Journal Name: INORGANICA CHIMICA ACTA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.121-125
Karadeniz Technical University Affiliated: Yes

Abstract

In this study, the synthesis of novel Monostyryl and Distyryl boron dipyrromethene dyes containing 4-((2-hydroxyethyl)(methyl)amino) group to determine neuroprotective potential has been reported for the first time. They were synthesized starting from BODIPY dye 1. Their inhibitory properties against Acetylcholinesterase/Butyrylcholinesterase (AChE/BuChE) and tyrosinase (Tyr) were evaluated according to Ingkaninan's and Masuda's methods and kinetic analysis of compounds was done using LineweaverBurk and Dixon plots. (C) 2017 Elsevier B.V. All rights reserved.