The diagnostic value of beta-human chorionic gonadotropin, progesterone, CA125 in the prediction of abortions


OSMANAĞAOĞLU M. A. , ERDOGAN I., EMINAGAOGLU S., KARAHAN S. C. , OZGUN S., ÇAN G. , ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.30, no.3, pp.288-293, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.3109/01443611003605286
  • Title of Journal : JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Page Numbers: pp.288-293
  • Keywords: Abortion, CA125, free beta-hCG, progesterone, EARLY-PREGNANCY FAILURE, SERUM CA-125 LEVELS, 1ST TRIMESTER, PROGNOSIS, ESTRADIOL, SUBUNIT

Abstract

This study was conducted to investigate the effectiveness of serum levels of free beta-hCG, progesterone, CA125 and their combined use in the prediction of first trimester abortions. A total of 140 singleton pregnant women between 5 and 13 weeks' gestational age were included as Group I (n = 21) who resulted in abortion including missed abortion, incomplete abortion, complete abortion and inevitable abortion; Group II (n = 129) included normal pregnancies. When using the free beta-hCG level of < 20 ng/ml as a cut off point, the sensitivity, specificity, PPV and NPV were 91%, 82%, 46% and 98%, when using a progesterone of < 15 ng/ml as a cut off point, they were 91%, 89%, 59%, 98%. The single measurement of free beta-hCG or progesterone levels can be useful in the prediction of first trimester spontaneous abortions, but using progesterone may be recommended since it has high availability and low cost.