The diagnostic value of beta-human chorionic gonadotropin, progesterone, CA125 in the prediction of abortions


OSMANAĞAOĞLU M. A., ERDOGAN I., EMINAGAOGLU S., KARAHAN S. C., OZGUN S., ÇAN G., ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.30, no.3, pp.288-293, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.3109/01443611003605286
  • Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.288-293
  • Keywords: Abortion, CA125, free beta-hCG, progesterone, EARLY-PREGNANCY FAILURE, SERUM CA-125 LEVELS, 1ST TRIMESTER, PROGNOSIS, ESTRADIOL, SUBUNIT
  • Karadeniz Technical University Affiliated: Yes

Abstract

This study was conducted to investigate the effectiveness of serum levels of free beta-hCG, progesterone, CA125 and their combined use in the prediction of first trimester abortions. A total of 140 singleton pregnant women between 5 and 13 weeks' gestational age were included as Group I (n = 21) who resulted in abortion including missed abortion, incomplete abortion, complete abortion and inevitable abortion; Group II (n = 129) included normal pregnancies. When using the free beta-hCG level of < 20 ng/ml as a cut off point, the sensitivity, specificity, PPV and NPV were 91%, 82%, 46% and 98%, when using a progesterone of < 15 ng/ml as a cut off point, they were 91%, 89%, 59%, 98%. The single measurement of free beta-hCG or progesterone levels can be useful in the prediction of first trimester spontaneous abortions, but using progesterone may be recommended since it has high availability and low cost.