The diagnostic value of beta-human chorionic gonadotropin, progesterone, CA125 in the prediction of abortions


OSMANAĞAOĞLU M. A. , ERDOGAN I., EMINAGAOGLU S., KARAHAN S. C. , OZGUN S., ÇAN G. , ...Daha Fazla

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.30, ss.288-293, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/01443611003605286
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Sayfa Sayıları: ss.288-293

Özet

This study was conducted to investigate the effectiveness of serum levels of free beta-hCG, progesterone, CA125 and their combined use in the prediction of first trimester abortions. A total of 140 singleton pregnant women between 5 and 13 weeks' gestational age were included as Group I (n = 21) who resulted in abortion including missed abortion, incomplete abortion, complete abortion and inevitable abortion; Group II (n = 129) included normal pregnancies. When using the free beta-hCG level of < 20 ng/ml as a cut off point, the sensitivity, specificity, PPV and NPV were 91%, 82%, 46% and 98%, when using a progesterone of < 15 ng/ml as a cut off point, they were 91%, 89%, 59%, 98%. The single measurement of free beta-hCG or progesterone levels can be useful in the prediction of first trimester spontaneous abortions, but using progesterone may be recommended since it has high availability and low cost.