In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: No tachyphylaxis effect

MUSICKI B., CHAMPION H., BECKER R., KRAMER M., LIU T., Sezen S., ...More

JOURNAL OF UROLOGY, vol.174, no.4, pp.1493-1496, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 174 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1097/01.ju.0000173006.47623.2c
  • Journal Name: JOURNAL OF UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1493-1496
  • Keywords: penis, impotence, rats, inbred F344, aging, phosphodiesterase inhibitors, NITRIC-OXIDE, DYSFUNCTION, EFFICACY, RAT, CITRATE, VITRO, MEN
  • Karadeniz Technical University Affiliated: No

Abstract

Purpose: Conflicting information exists regarding the long-term efficacy of phosphodiesterase-5 (PDE5) inhibitor therapy for erectile dysfunction, particularly in regard to whether therapeutic resistance occurs. We investigated the erectile response, and cavernous PDE5 expression and activity after continuous long-term administration of sildenafil at verified therapeutic plasma concentrations, applying an in vivo rat model of age related erectile dysfunction.