In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: No tachyphylaxis effect

MUSICKI, FERİDE; CHAMPION, HC; BECKER, RE; KRAMER, MF; LIU, TY; Sezen, SF; BURNETTT, AL

doi:10.1097/01.ju.0000173006.47623.2c

In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: No tachyphylaxis effect

Atıf İçin Kopyala

MUSICKI B. , CHAMPION H., BECKER R., KRAMER M., LIU T., Sezen S., ...Daha Fazla

JOURNAL OF UROLOGY, cilt.174, ss.1493-1496, 2005 (SCI İndekslerine Giren Dergi)

Cilt numarası: 174 Konu: 4
Basım Tarihi: 2005
Doi Numarası: 10.1097/01.ju.0000173006.47623.2c
Dergi Adı: JOURNAL OF UROLOGY
Sayfa Sayıları: ss.1493-1496

Özet

Purpose: Conflicting information exists regarding the long-term efficacy of phosphodiesterase-5 (PDE5) inhibitor therapy for erectile dysfunction, particularly in regard to whether therapeutic resistance occurs. We investigated the erectile response, and cavernous PDE5 expression and activity after continuous long-term administration of sildenafil at verified therapeutic plasma concentrations, applying an in vivo rat model of age related erectile dysfunction.