In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: No tachyphylaxis effect

MUSICKI B., CHAMPION H., BECKER R., KRAMER M., LIU T., Sezen S., ...Daha Fazla

JOURNAL OF UROLOGY, cilt.174, sa.4, ss.1493-1496, 2005 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 174 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1097/01.ju.0000173006.47623.2c
  • Dergi Adı: JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1493-1496
  • Anahtar Kelimeler: penis, impotence, rats, inbred F344, aging, phosphodiesterase inhibitors, NITRIC-OXIDE, DYSFUNCTION, EFFICACY, RAT, CITRATE, VITRO, MEN
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Purpose: Conflicting information exists regarding the long-term efficacy of phosphodiesterase-5 (PDE5) inhibitor therapy for erectile dysfunction, particularly in regard to whether therapeutic resistance occurs. We investigated the erectile response, and cavernous PDE5 expression and activity after continuous long-term administration of sildenafil at verified therapeutic plasma concentrations, applying an in vivo rat model of age related erectile dysfunction.