Premedication with melatonin vs midazolam in anxious children

Isik B. , Baygin O., Bodur H.

PEDIATRIC ANESTHESIA, vol.18, no.7, pp.635-641, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 7
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1460-9592.2008.02608.x
  • Title of Journal : PEDIATRIC ANESTHESIA
  • Page Numbers: pp.635-641
  • Keywords: melatonin, midazolam, sedation, anxious children, dentistry, SLEEP DISORDERS, DOUBLE-BLIND, SEDATION, PROPOFOL, MRI


Aim: Failure of dental treatment caused by anxiety is a common problem in children. Oral midazolam has been the most commonly used premedication for pediatric patient but the use of midazolam may be associated with paradoxical reactions in children. Melatonin may induce a natural sleepiness and improve sedation. We have investigated premedication with melatonin compared with midazolam in children under nitrous oxide/oxygen (N2O/O-2) sedation for dental treatment.