Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1 % ophthalmic solutions in seasonal allergic conjunctivitis: A 30-day, randomized, double-masked, artificial tear substitute-controlled trial

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Avunduk A., Tekelioglu Y., Turk A., Akyol N.

CLINICAL THERAPEUTICS, vol.27, no.9, pp.1392-1402, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 9
  • Publication Date: 2005
  • Doi Number: 10.1016/j.clinthera.2005.09.013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1392-1402
  • Karadeniz Technical University Affiliated: Yes


Background: Topical antiallergic agents, such as antihistamines and mast-cell stabilizers, are the main therapeutic options for seasonal allergic conjunctivitis (SAC). Ketotifen fumarate and olopatadine HCl have dual action that offers a combination of these 2 mechanisms. Although clinical studies comparing the efficacy of these 2 drugs have shown that both were effective in the treatment of SAC, the results were contradictory and did not include the effects of these drugs on inflammatory markers.