Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1 % ophthalmic solutions in seasonal allergic conjunctivitis: A 30-day, randomized, double-masked, artificial tear substitute-controlled trial

AVUNDUK A., Tekelioglu Y. , TURK A., AKYOL N.

CLINICAL THERAPEUTICS, cilt.27, ss.1392-1402, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27 Konu: 9
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.clinthera.2005.09.013
  • Sayfa Sayıları: ss.1392-1402


Background: Topical antiallergic agents, such as antihistamines and mast-cell stabilizers, are the main therapeutic options for seasonal allergic conjunctivitis (SAC). Ketotifen fumarate and olopatadine HCl have dual action that offers a combination of these 2 mechanisms. Although clinical studies comparing the efficacy of these 2 drugs have shown that both were effective in the treatment of SAC, the results were contradictory and did not include the effects of these drugs on inflammatory markers.