This study is aimed at determining some of the plants traditionally used in the treatment of diseases by the local people living in Kastamonu province center and surrounding villages. A face-to-face questionnaire was applied and semi-structured interviews were conducted with 52 informants, 34 women and 18 men. Identification of 92 plants belonging to 41 families has been confirmed and their medicinal uses have been recorded. The most used families were Rosaceae (13 taxa), Asteraceae (11), and Lamiaceae (11). The most preferred folk recipes of medicinal plants was decoction (55 taxa) and in preparations and applications, the most used were the leaves (45 taxa). According to the International Classification of Primary Care categories, plants were the most used for digestive disorders (37 taxa), respiratory disorders (27 taxa), and urological disorders (24 taxa). The highest use-value was recorded for Urtica dioica (0.519), and highest relative frequency citation was recorded for Tilia rubra subsp. caucasica (0.231). Male genital diseases had the highest informant consensus factor value (0.83). New areas of use were also determined for Pilosella leucopsilon subsp. pilisquama, Galium palustre, and Astragalus nitens. With this study, new information for folkloric medicines is presented and the usage of herbal drugs in the study area are enhanced.