Akademik Veri Yönetim Sistemi
7. Uluslararası Muğla Arıcılık ve Çam Balı Kongresi, Muğla, Türkiye, 15 - 19 Kasım 2022, ss.91-92
Propolis and royal jelly are natural beekeeping products and are widely used in both traditional medicine
and modern medicine thanks to their antioxidant, antimicrobial, anti-inflammatory, anti-aging and wound healing
effects. Today, there are many cosmetic products in which bee products are utilized. There are products containing
propolis and royal jelly separately, but no product containing both together has been found, when we look at the bee
product-based cosmetic products in the Turkish market. Propolis is used raw in existing products and it has been
observed that the deterioration process of royal jelly is not taken into account. However, raw propolis contains
impurities in the form of wax, which are highly insoluble, and its active components are between 1-3%. The
objective of the current study is to develop a skin cream formulation based on propolis and royal jelly to take
advantage of the antioxidant, antimicrobial, anti-aging and skin rejuvenation effects of them. For this purpose, three
different cream formulations were prepared. A fixed ratio of 0.5% royal jelly and 0.5%, 1.0%, 1.5% propolis extract
was added into the cream formulation. The antihyaluronidase, antioxidant and antimicrobial analyzes of the cream
samples and stability tests for 30 days at three different temperatures were carried out. The bioactivity values of the
creams with propolis and royal jelly were statistically different from the control group when the analysis results
were evaluated. 1.5% propolis extract added cream showed the highest values of total phenolic content, total
flavonoid content and FRAP value, the values were found as 0.785±0.081 mg GAE/mg sample, 0.448±0.042 mg
quercetin/g sample and 4.004±0.377 µmol Trolox/g sample, respectively. During storage, phase separation was not
observed in all cream samples and there was no significant change in pH and color values. It was defined that
creams containing propolis extract and royal jelly presented antihyaluronidase activity. In addition, the use of
propolis extract increased the antioxidant properties in creams and so increased the strength of royal jelly, which
can be rapidly deteriorated and oxidized due to its structure. The results of the study showed that the cream
formulation containing both propolis and royal jelly could produce successfully.
Keywords: Cream, Cosmetics, Propolis, Royal jelly, Skin Rejuvenation