Akademik Veri Yönetim Sistemi
Gümüşhane Üniversitesi Fen Bilimleri Dergisi, cilt.10, sa.3, ss.681-694, 2020 (Hakemli Dergi)
In this study, new thiophene Schiff bases with morpholine (1,2) were synthesized. The structures of the compoundswere confirmed by 1H-NMR, 13C-NMR and IR spectrometry and their antioxidant, antibacterial, antileishmanial andenzyme activities were tested. The antioxidant activities observed from compounds 1 and 2 were remarkably high.According to the results obtained in our study, the compounds did not have antileishmanial activity (MIC >20000µg/ml). It was determined that the synthesized compounds had different rates of antibacterial activity against ninedifferent standard bacterial isolates. Enzyme inhibition effect of the compounds 1 and 2 was unimportant level and thecompound exhibited low binding affinity against the enzyme in molecular docking studies. The compounds 1 and 2formed many 𝜋 interactions with active site residue, however, they do not inhibit the enzyme due to did not interactwith key residues of the enzymes. Our in silico and in vitro studies results were compatible with each other. As a result,the compounds 1 and 2 may be used as antioxidant and antimicrobial drugs, If they can be investigated as drugcandidates.