Akademik Veri Yönetim Sistemi
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE, sa.10, ss.672-676, 2024 (ESCI)
Aim: Liver biopsy is the gold standard in the diagnosis of Liver Fibrosis (LF) and Nonalcoholic Steatohepatitis (NASH). Liver biopsy is the gold standard in the diagnosis of Liver Fibrosis (LF) and Nonalcoholic Steatohepatitis (NASH). Its invasiveness limits its use. However, the reliability of non-invasive markers is still controversial. In this study, according to the results of liver biopsy in patients with LF and NASH; Fibrosis-4 Index (FIB-4), Aspartate Aminotransferase Platelet Ratio Index (APRI), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV), and Mean Platelet Volume/Platelet Ratio (MPR) we aimed to reveal the relationship. Material and Methods: 1350 liver biopsies were reviewed retrospectively. 197 patients (88 men and 109 women) who met the criteria were included in the study. All pathology results were re-evaluated with Fibrosis score (FS) and Nonalcoholic Fatty Liver Disease Activity Score (NAS). Efforts were made to exclude possible disturbing factors that may affect hematological parameters. NLR, PLR, MPV, MPR, APRI and FIB-4 values were calculated and the relationship between NAS score and FS was examined. Results: APRI was significant according to the results with and without NASH (p=0.002). In patients with LF; MPR, MPV, APRI, FIB-4 values were statistically significant and correlated compared to those without fibrosis. (p<0.001, p=0.029, p=0.001, p<0.001, respectively). Surprisingly, there was no statistically significant relationship between PLR and NLR, neither NASH nor LF (p<0.18, p=0.60 respectively). Discussion: This study is one of the few studies with biopsy results. For the reliability of these parameters, extensive studies are needed in this area.