Effect of Turkish propolis extracts on proteome of prostate cancer cell line

Creative Commons License

Barlak Y., DEĞER O., Colak M., Karatayli S. C., Bozdayi A. M., Yucesan F.

PROTEOME SCIENCE, cilt.9, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1186/1477-5956-9-74
  • Dergi Adı: PROTEOME SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Propolis, PC-3 Prostate Cancer Cell Line, Proteome, SELDI-TOF MS, BRAZILIAN PROPOLIS, DIETARY AGENTS, CHEMOPREVENTION, PRODUCTS, PROGRESS, ORIGIN
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Propolis is a natural, resinous hive product that has several pharmacological activities. Its composition varies depending on the vegetation, climate, season and environmental conditions of the area from where it was collected. Surface enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF MS) is a proteomic approach which has been used in cancer proteomics studies. Prostate cancer is one of the most commonly diagnosed cancers in men. It has shown that nutritional supplements rich in polyphenolic compounds such as propolis play a significant role in prostate cancer chemoprevention. The aim of this study is to evaluate if protein expression profile in PC-3 prostate cancer cell lines could be differentiated when incubated with dimethyl sulfoxide and water extracts of Turkish propolis.