Effects of interferon-alpha-2a on Th3 cytokine response in multiple myeloma patients


Sonmez M. , Sonmez B. , EREN N., Yilmaz M. , KARTİ S. S. , OVALI E.

TUMORI J, cilt.90, sa.4, ss.387-389, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90 Konu: 4
  • Basım Tarihi: 2004
  • Dergi Adı: TUMORI J
  • Sayfa Sayıları: ss.387-389

Özet

Aims and background: Multiple myeloma cells increase Th3 cytokine response by secreting TGF-beta, which causes defective Th1 and Th2 cytokine responses. Therefore, a significant suppression of the immune system is seen in multiple myeloma. Interferon-alpha (IFN-alpha) is used in the treatment of multiple myeloma due to its immunomodulatory and anti-tumoral effects. We attempted to define the characteristics of immune cytokine responses and the effects of IFN-alpha-2a on the immune response in multiple myeloma.