Effects of interferon-alpha-2a on Th3 cytokine response in multiple myeloma patients

Sonmez M. , Sonmez B. , EREN N., Yilmaz M. , KARTİ S. S. , OVALI E.

TUMORI J, vol.90, no.4, pp.387-389, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 90 Issue: 4
  • Publication Date: 2004
  • Title of Journal : TUMORI J
  • Page Numbers: pp.387-389


Aims and background: Multiple myeloma cells increase Th3 cytokine response by secreting TGF-beta, which causes defective Th1 and Th2 cytokine responses. Therefore, a significant suppression of the immune system is seen in multiple myeloma. Interferon-alpha (IFN-alpha) is used in the treatment of multiple myeloma due to its immunomodulatory and anti-tumoral effects. We attempted to define the characteristics of immune cytokine responses and the effects of IFN-alpha-2a on the immune response in multiple myeloma.