Effects of interferon-alpha-2a on Th3 cytokine response in multiple myeloma patients
TUMORI J, vol.90, no.4, pp.387-389, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 90 Issue: 4
- Publication Date: 2004
- Journal Name: TUMORI J
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.387-389
- Karadeniz Technical University Affiliated: Yes
Abstract
Aims and background: Multiple myeloma cells increase Th3 cytokine response by secreting TGF-beta, which causes defective Th1 and Th2 cytokine responses. Therefore, a significant suppression of the immune system is seen in multiple myeloma. Interferon-alpha (IFN-alpha) is used in the treatment of multiple myeloma due to its immunomodulatory and anti-tumoral effects. We attempted to define the characteristics of immune cytokine responses and the effects of IFN-alpha-2a on the immune response in multiple myeloma.