Effects of interferon-alpha-2a on Th3 cytokine response in multiple myeloma patients
TUMORI J, cilt.90, sa.4, ss.387-389, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 90 Sayı: 4
- Basım Tarihi: 2004
- Dergi Adı: TUMORI J
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.387-389
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Aims and background: Multiple myeloma cells increase Th3 cytokine response by secreting TGF-beta, which causes defective Th1 and Th2 cytokine responses. Therefore, a significant suppression of the immune system is seen in multiple myeloma. Interferon-alpha (IFN-alpha) is used in the treatment of multiple myeloma due to its immunomodulatory and anti-tumoral effects. We attempted to define the characteristics of immune cytokine responses and the effects of IFN-alpha-2a on the immune response in multiple myeloma.