Effects of interferon-alpha-2a on Th3 cytokine response in multiple myeloma patients

Sonmez M., Sonmez B., EREN N., Yilmaz M., KARTİ S. S., OVALI E.

TUMORI J, cilt.90, sa.4, ss.387-389, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90 Sayı: 4
  • Basım Tarihi: 2004
  • Dergi Adı: TUMORI J
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.387-389
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Aims and background: Multiple myeloma cells increase Th3 cytokine response by secreting TGF-beta, which causes defective Th1 and Th2 cytokine responses. Therefore, a significant suppression of the immune system is seen in multiple myeloma. Interferon-alpha (IFN-alpha) is used in the treatment of multiple myeloma due to its immunomodulatory and anti-tumoral effects. We attempted to define the characteristics of immune cytokine responses and the effects of IFN-alpha-2a on the immune response in multiple myeloma.