Synthesis of 2-acylamino, 2-aroylamino and ethoxycarbonyl imino-1,3,4-thiadiazoles as antitumor agents

Sancak K., Unver Y., Er M.

TURKISH JOURNAL OF CHEMISTRY, cilt.31, sa.2, ss.125-134, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2007
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.125-134
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

2-Amino-1,3,4-thiadiazoles compounds (2a-e) were obtained from the reaction of thiosemi carbazide with 2-cyanomethoxyphenoxyacetonitriles (1). Mono acylamino, mono aroylamino and diethoxycarbonylimino-1,3,4-thiadiazole compounds (3a-e, 4a-e, 5a-c) were synthesized via the reaction of 2-amino-1,3,4-thiadiazole compounds (2a-e) with acetyl chloride or acetic anhydride, benzoyl chloride or benzoic anhydride and ethyl chloroformate, respectively.