TREATMENT OF ACUTE SPINAL-CORD INJURIES - COMPARISON OF THYROTROPIN-RELEASING-HORMONE AND NIMODIPINE

CEYLAN S., Ilbay K., BAYKAL S., CEYLAN S., SENER U., OZMENOGLU M., ...More

RESEARCH IN EXPERIMENTAL MEDICINE, vol.192, no.1, pp.23-33, 1992 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 192 Issue: 1
  • Publication Date: 1992
  • Doi Number: 10.1007/bf02576254
  • Journal Name: RESEARCH IN EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.23-33
  • Karadeniz Technical University Affiliated: Yes

Abstract

The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3 ml) i.v. 1 h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3 ml) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P < 0.01).