Adrenal black adenoma associated with Cushing's syndrome

Erem C. , Hacihasanoglu A., Cinel A., Cobanoglu U. , Ersoz H., Ahmetoglu A., ...Daha Fazla

ENDOCRINE, cilt.25, ss.253-257, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 25 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1385/endo:25:3:253
  • Dergi Adı: ENDOCRINE
  • Sayfa Sayıları: ss.253-257


We report a case of adrenal black adenoma associated with Cushing's syndrome. A 41 -yr-old man presented to our hospital with a 6-yr history of severe hypertension and general fatigue, and a 1 -mo history of diabetes mellitus. Physical examination disclosed cushing-oid manifestations. His serum cortisol concentrations ranged from 14.0 to 15.4 mu g/dL, with an ACTH level < 5 pg/mL. Urinary free cortisol level was increased (125 mu g/d). Cortisol was not suppressed on the overnight 1 mg oral dexamethasone suppression test (DST), 2-d low dose DST, and 2-d high-dose DST. Abdominal computed tomography and magnetic resonance imaging studies revealed a solid round tumor approx 3 cm in diameter, located in the left adrenal gland. Left adrenalectomy was performed; the surgical specimen revealed a black adenoma consisting of compact cells within numerous pigments that seemed to be lipofuscin in nature.