Journal of Molecular Structure, vol.1330, 2025 (SCI-Expanded)
This study aimed to examine the synthesis, characterization, in vitro cholinesterase inhibition, and cytotoxic activity of silicon (IV) phthalocyanine containing anthraquinone groups against colorectal and lung cancer cells. First, 2-(3-hydroxypropoxy)anthra-9,10-quinone was obtained from the reaction of 2-hydroxyanthraquinone with 3‑chloro-1-propanol. Then, axially anthraquinone-substituted silicon phthalocyanines were synthesized by reacting SiPcCl2 with ANT-C3-OH and ANT-OH2. These phthalocyanines were characterized by using FT-IR, 1HNMR, 13CNMR, UV–vis, and mass spectra. Next, in vitro cholinesterase inhibition and cytotoxic activity of silicon (IV) phthalocyanine containing anthraquinone groups (ANT-C3-Si and ANT-OH2-Si) on human colorectal carcinoma (HCT-116) and human lung adenocarcinoma (A549) cells were investigated. Results showed that ANT-C3-Si exhibited greater AChE inhibition than ANT-OH2-Si, with IC50 value of 70.42 ± 2.50 µM. According to (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis, ANT-C3-Si demonstrated higher cytotoxic effects in both cell lines after 24 h The study findings suggest that ANT-C3-Si has potential for use in Alzheimer's disease due to its lower IC₅₀ value and cytotoxic potential.