Combination of Histone Deacetylase Inhibitor with Cu(II) 5,5-diethylbarbiturate Complex Induces Apoptosis in Breast Cancer Stem Cells: A Promising Novel Approach

Erkisa M., Aztopal N., ERTÜRK E., Ulukaya E., YILMAZ V. T., ARI F.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.21, sa.14, ss.1850-1860, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 14
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1871520621666201207090702
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1850-1860
  • Anahtar Kelimeler: Epigenetic modulators, valproic acid, Cu(II) complex, breast cancer stem cell, apoptosis, histone deacetylase inhibitor, COPPER COMPLEX, VALPROIC ACID, IN-VITRO, ANTICANCER ACTIVITY, DNA/BSA BINDING, METAL-COMPLEXES, DNA CLEAVAGE, ROS, PATHWAY, DIFFERENTIATION
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background: Cancer Stem Cells (CSCs) are a subpopulation within the tumor that play a role in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes lead to tumor formation in cancer stem cells and show drug resistance. Epigenetic modulators and /or their combination with different agents have been used in cancer therapy.