Rapid and Efficient Microwave-Assisted Synthesis of Some New Triazol-3-one Derivatives

MENTEŞE E., ÖZİL M., Karaoglu S. A., Kahveci B.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.50, no.2, pp.386-390, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1002/jhet.946
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.386-390
  • Karadeniz Technical University Affiliated: No

Abstract

A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new triazol-3-ones via microwave heating using a monomode microwave. Compared with the thermal process, the microwave heating induces a dramatic reduction of the reaction time and improvement of the yields. In this study, rapid N-benzylation and N-acetylation of triazol-3-ones were achieved by microwave irradiation method for the first time. The newly synthesized compounds showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested.