Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

OZDEMIR S. B., CEBECI Y. U., BAYRAK H., MERMER A., Ceylan S., DEMİRBAŞ A., ...Daha Fazla

HETEROCYCLIC COMMUNICATIONS, cilt.23, sa.1, ss.43-54, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1515/hc-2016-0125
  • Dergi Adı: HETEROCYCLIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.43-54
  • Anahtar Kelimeler: antimicrobial activity, conazole, Mannich base, microwave, piperazine, MICROWAVE-ASSISTED SYNTHESIS, HYBRID MOLECULES, ONE-POT, BIOLOGICAL EVALUATION, DERIVATIVES, BEARING, DESIGN
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. The condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. The synthesized compounds were screened for their antimicrobial activities.