Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds


OZDEMIR S. B. , CEBECI Y. U. , BAYRAK H., MERMER A., Ceylan S., DEMİRBAŞ A., ...More

HETEROCYCLIC COMMUNICATIONS, vol.23, no.1, pp.43-54, 2017 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1515/hc-2016-0125
  • Journal Name: HETEROCYCLIC COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.43-54
  • Keywords: antimicrobial activity, conazole, Mannich base, microwave, piperazine, MICROWAVE-ASSISTED SYNTHESIS, HYBRID MOLECULES, ONE-POT, BIOLOGICAL EVALUATION, DERIVATIVES, BEARING, DESIGN

Abstract

The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. The condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. The synthesized compounds were screened for their antimicrobial activities.