L-theanine alleviates liver and kidney dysfunction in septic rats induced by cecal ligation and puncture


MALKOÇ M. , Patan H., ÖZER YAMAN S. , TÜREDİ S. , KERİMOĞLU G. , KURAL B. , ...More

LIFE SCIENCES, vol.249, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 249
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.117502
  • Title of Journal : LIFE SCIENCES
  • Keywords: L-theanine, Sepsis, CLP, Oxidative stress, Inflammation, Apoptosis, EXPERIMENTAL SEPSIS, OXIDATIVE STRESS, INJURY, GLYCINE, INFLAMMATION, CYTOKINES, GREEN, ACID

Abstract

Aims: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response against infection that triggers systemic inflammatory response syndrome. L-theanine (LT), a glutamate derivative, is a non-protein amino acid derived from tea (Camellia sinensis), and a valuable nutraceutical product used as an additive in the food industry. This study we aimed to investigate whether LT would exert any therapeutic effect on liver and kidney tissues in Sprague Dawley rats with sepsis induced with cecal ligation and puncture (CLP).