Detection of chromosomal aberrations in prostate cancer by fluorescence in situ hybridization (FISH)


Celep F. , KARAGUZEL A., OZGUR G., YILDIZ K.

EUROPEAN UROLOGY, cilt.44, ss.666-671, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 44 Konu: 6
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0302-2838(03)00414-7
  • Dergi Adı: EUROPEAN UROLOGY
  • Sayfa Sayıları: ss.666-671

Özet

Purpose: Fluorescence in situ hybridization (FISH) is a powerful tool for quantitative analysis of chromosomes and genes and can be applied in a variety of specimens, including cell cultures, isolated nuclei from fresh and fixed tissues, and histological tissue sections. For detection of numerical chromosome aberrations, we examined prostatic cancer samples at our department. In addition, we also observed primary and secondary aberrations taking part in the initiation and progression of tumours.