Detection of chromosomal aberrations in prostate cancer by fluorescence in situ hybridization (FISH)

Celep F., KARAGUZEL A., OZGUR G., YILDIZ K.

EUROPEAN UROLOGY, vol.44, no.6, pp.666-671, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.1016/s0302-2838(03)00414-7
  • Journal Name: EUROPEAN UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.666-671
  • Karadeniz Technical University Affiliated: Yes

Abstract

Purpose: Fluorescence in situ hybridization (FISH) is a powerful tool for quantitative analysis of chromosomes and genes and can be applied in a variety of specimens, including cell cultures, isolated nuclei from fresh and fixed tissues, and histological tissue sections. For detection of numerical chromosome aberrations, we examined prostatic cancer samples at our department. In addition, we also observed primary and secondary aberrations taking part in the initiation and progression of tumours.