Synthesis and Biological Evaluation of New Tricyclic Dihydropyridine Based Derivatives on Potassium Channels

Gündüz M. G., KAYA Y., Şimşek R., Sahin-Erdemli İ., Şafak C.

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, vol.15, no.4, pp.763-775, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2016
  • Journal Name: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.763-775
  • Karadeniz Technical University Affiliated: No

Abstract

The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis.