ELECTROCHEMICAL DETERMINATION OF ANTI-HYPERLIPIDEMIC DRUG EZETIMIBE BASED ON ITS OXIDATION ON SOLID ELECTRODES


KUL D., Uslu B., Ozkan S. A.

ANALYTICAL LETTERS, vol.44, no.7, pp.1341-1357, 2011 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 7
  • Publication Date: 2011
  • Doi Number: 10.1080/00032719.2010.512676
  • Journal Name: ANALYTICAL LETTERS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1341-1357
  • Keywords: Boron-doped diamond electrode, Ezetimibe, Glassy carbon electrode, Pharmaceuticals, Voltammetry, PHARMACEUTICAL FORMULATIONS, ATORVASTATIN CALCIUM, LIQUID-CHROMATOGRAPHY, TABLET FORMULATION, DIFFERENTIAL-PULSE, DOSAGE FORMS, HPTLC METHOD, VALIDATION, SIMVASTATIN, VOLTAMMETRY

Abstract

Ezetimibe is the first of a new class of drugs that selectively inhibits cholesterol absorption in the small intestine and reduces plasma LDL cholesterol. In this study, electrochemical oxidation of ezetimibe was investigated on carbon based electrodes and a single and irreversible peak at both electrodes was observed. A linear response was detected between 2 x 10(-6) and 8 x 10(-5) M with glassy carbon electrode and between 2 x 10(-6) and 2 x 10(-4) M with a boron-doped diamond electrode in 0.1 M H2SO4 supporting electrolyte. The proposed methods were successfully applied for the determination of ezetimibe from pharmaceutical dosage forms and human serum samples.