ELECTROCHEMICAL DETERMINATION OF ANTI-HYPERLIPIDEMIC DRUG EZETIMIBE BASED ON ITS OXIDATION ON SOLID ELECTRODES

KUL D., Uslu B., Ozkan S. A.

ANALYTICAL LETTERS, cilt.44, sa.7, ss.1341-1357, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 7
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1080/00032719.2010.512676
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1341-1357
  • Anahtar Kelimeler: Boron-doped diamond electrode, Ezetimibe, Glassy carbon electrode, Pharmaceuticals, Voltammetry, PHARMACEUTICAL FORMULATIONS, ATORVASTATIN CALCIUM, LIQUID-CHROMATOGRAPHY, TABLET FORMULATION, DIFFERENTIAL-PULSE, DOSAGE FORMS, HPTLC METHOD, VALIDATION, SIMVASTATIN, VOLTAMMETRY
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Ezetimibe is the first of a new class of drugs that selectively inhibits cholesterol absorption in the small intestine and reduces plasma LDL cholesterol. In this study, electrochemical oxidation of ezetimibe was investigated on carbon based electrodes and a single and irreversible peak at both electrodes was observed. A linear response was detected between 2 x 10(-6) and 8 x 10(-5) M with glassy carbon electrode and between 2 x 10(-6) and 2 x 10(-4) M with a boron-doped diamond electrode in 0.1 M H2SO4 supporting electrolyte. The proposed methods were successfully applied for the determination of ezetimibe from pharmaceutical dosage forms and human serum samples.