Vitamin D Deficiency During the First Trimester of Pregnancy and the Risk of Developing Gestational Diabetes Mellitus

Aslan Çin N. N., Yalçin M., Yardimci H.

JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing, vol.51, no.5, pp.526-535, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1016/j.jogn.2022.06.038
  • Journal Name: JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CAB Abstracts, Child Development & Adolescent Studies, CINAHL, EMBASE, Gender Studies Database, MEDLINE, Psycinfo, Veterinary Science Database, DIALNET
  • Page Numbers: pp.526-535
  • Keywords: 25-hydroxyvitamin D, fasting blood glucose, gestational diabetes mellitus, insulin resistance, oral glucose tolerance test, 25-HYDROXYVITAMIN D LEVELS, METAANALYSIS, ASSOCIATIONS, DIAGNOSIS, INCREASES, OUTCOMES, OBESITY, WOMEN
  • Karadeniz Technical University Affiliated: Yes


© 2022 AWHONN, the Association of Women's Health, Obstetric and Neonatal NursesObjective: To investigate the relationships among various factors that affect serum vitamin D levels and vitamin D in the first trimester and the risk of developing gestational diabetes mellitus (GDM). Design: A prospective cohort design. Setting: The family health center of Ankara, Turkey. Participants: Out of 889 pregnant women who participated in the study in the first trimester (6–13 weeks gestation), 814 participated in GDM screening in the second trimester (24–28 weeks gestation). Methods: We determined serum vitamin D levels, demographic data, various biochemical and anthropometric parameters, and factors that affect vitamin D synthesis of participants in the first trimester and used logistic regression analysis to analyze the effects of the associations among vitamin D deficiency and the other variables on the occurrence of GDM. Results: Vitamin D deficiency in the first trimester was present in 425 (82.5%) participants. In the second trimester, 198 participants (24.3%) were diagnosed with GDM through oral glucose tolerance test screening. We detected GDM in the second trimester in 5.7% of participants who had vitamin D deficiency in the first trimester. Even after adjustment for vitamin D intake, clothing style, and duration of exposure to the sun, the risk of GDM was significantly greater in participants who were vitamin D deficient than those who were not deficient. The risk of GDM among women with vitamin D deficiency was sustained or increased significantly after we adjusted for age, parity, prepregnancy body mass index, history of diabetes, triglyceride levels, vitamin D intake, clothing style, and length of sun exposure, OR = 10.60, p < .001, 95% confidence interval [2.82, 39.76]. Conclusions: Our results suggest that vitamin D deficiency in the first trimester may significantly increase the risk of developing GDM.