Role of L-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats

Demirdag K., Bahcecioglu I., Ozercan I., Ozden M., Yilmaz S., Kalkan A.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.19, sa.3, ss.333-338, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1440-1746.2003.03291.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.333-338
  • Anahtar Kelimeler: acute liver damage, carbon tetrachloride, L-carnitine, lipid peroxidation, LIPID-PEROXIDATION, CIRRHOSIS, DISEASE, METABOLISM, TOXICITY, FIBROSIS, ACID
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background and Aim: Lipid peroxidation is the most important mechanism in the pathogenesis of acute liver damage with carbon tetrachloride (CCl4). L-carnitine may prevent lipid peroxidation and thus may protect against liver damage. In the present study we investigated the protective effect of L-carnitine in experimental acute liver damage induced by CCl4.