Role of L-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats

Demirdag K., Bahcecioglu I., Ozercan I., Ozden M., Yilmaz S., Kalkan A.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.19, no.3, pp.333-338, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1440-1746.2003.03291.x
  • Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.333-338
  • Keywords: acute liver damage, carbon tetrachloride, L-carnitine, lipid peroxidation, LIPID-PEROXIDATION, CIRRHOSIS, DISEASE, METABOLISM, TOXICITY, FIBROSIS, ACID
  • Karadeniz Technical University Affiliated: No

Abstract

Background and Aim: Lipid peroxidation is the most important mechanism in the pathogenesis of acute liver damage with carbon tetrachloride (CCl4). L-carnitine may prevent lipid peroxidation and thus may protect against liver damage. In the present study we investigated the protective effect of L-carnitine in experimental acute liver damage induced by CCl4.