Is ceftriaxone effective in experimental brain ischemia/reperfusion injury?

Arslan E., Biyik M. O., Kosucu M., Guvercin A. R., Bodur A., Alver A.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, no.12, pp.858-863, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_141
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.858-863
  • Keywords: ceftriaxone, ischemia/reperfusion injury, antioxidant, neuroprotective, stroke, ACUTE ISCHEMIC-STROKE, RAT MODEL, MECHANISMS, PATHOPHYSIOLOGY, OCCLUSION, THERAPY
  • Karadeniz Technical University Affiliated: Yes


OBJECTIVE: The aim of the present study was to investigate the neuroprotective effect of ceftriaxone in a rat brain ischemia/reperfusion injury model. METHODS: The oxidative stress parameter, malondialdehyde (MDA) levels with or without ceftriaxone treatment in brain ischemia/reperfusion injured rats as well as in controls were measured in serum and brain tissue. Motor examinations of the rats were also performed. One-way Analysis of Variance (ANOVA) test was used for analysis. Duncan's Multiple Range Test was performed in multiple comparisons. p < 0.05 were considered statistically significant. RESULTS: The data of this study showed that ceftriaxone treatment reduced the MDA levels in brain tissues in ischemia/reperfusion injured rats. Moreover, Bederson motor scores were higher in the ceftriaxone treated group as compared to the ischemia group (p = 0.092). CONCLUSION: These results suggest that ceftriaxone could be beneficial for the prevention of brain ischemia/reperfusion injury caused by acute arterial occlusion through reducing the tissue MDA level (Tab. 2, Ref. Text in PDF