Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) levels in patients with overt and subclinical hyperthyroidism: effects of treatment

EREM C. , CİVAN N. , COSKUN H. , MENTEŞE A. , SÜLEYMAN A. K. , ALTAY D. U. , ...Daha Fazla

CLINICAL ENDOCRINOLOGY, cilt.84, sa.6, ss.919-924, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/cen.12955
  • Sayfa Sayıları: ss.919-924


Background and ObjectivesSignal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) has been shown to increase in parallel with platelet activation in acute ischaemic and thrombotic diseases. There has been no study evaluating SCUBE1 levels in patients with overt hyperthyroidism (OHyper) and subclinical hyperthyroidism (SHyper), conditions which are known to show impairment of both endothelial and platelet function. This study sought to evaluate SCUBE1 concentrations in patients with SHyper and OHyper, and assessed the effects of antithyroid drug (ATD) therapy on circulating SCUBE1 levels.