Akademik Veri Yönetim Sistemi
2. Uluslararası Sağlık, Farmakoloji ve Veterinerlik Kongresi, Ankara, Türkiye, 21 - 22 Mayıs 2022, ss.64-72
Chondroitin Sulfate is a sulfated glycosaminoglycan from different carbon positions composed of repeating disaccharide units of N-acetyl-galactosamine (GalNAc) and glucuronic acid (GlcA). Although chondroitin sulfate is found in the sulfated form in mammals, it has also been found to exist in the sulfate-free form in nature. As part of the cellular microenvironment, chondroitin sulfate is associated with various aspects of tumor progression and metastasis, depending on the sulfate pattern of chondroitin sulfate. This study evaluated the potential roles of microbial Chondroitin for tumor growth and metastasis in MDA-MB-231 metastatic breast cancer cells, HeLa cervical cancer cells, and normal fibroblasts. While microbial Chondroitin at examined concentrations was not cytotoxic in HeLa cells, it was cytotoxic for MDA-MB-231 cells but without selectivity over normal cells. The anti-metastatic role of microbial Chondroitin was also evaluated by wound healing assay. Microbial Chondroitin has been found to inhibit cell migration in normal cells compared to cancer cells. Microbial Chondroitin has a cytotoxic effect on MDA-MB231 cells but not an anti-metastatic effect. These suggest that microbial Chondroitin may have a selective cytotoxic effect on some other cancer cells not examined in this study, suggesting the possible cancer-type specificity for its action.