Synthesis of axially disubstituted silicon phthalocyanines and investigation of their in vitro cytotoxic/phototoxic anticancer activities

Yurt F., SAKA E. T. , BIYIKLIOĞLU Z., Tuncel A., Ozel D., Ocakoglu K.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol.25, no.1, pp.10-18, 2021 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1142/s1088424620500455
  • Journal Indexes: Science Citation Index Expanded, Scopus, Chemical Abstracts Core, Chimica
  • Page Numbers: pp.10-18


In this study, two SiPcs have been selected and the photodynamic therapy potentials were evaluated of the Pcs. Synthesis of Axially 2-decyn-1-oxy disubstituted Es-SiPc-2 was newly synthesized by the reaction of SiPcCl2 with 2-decyn-1-ol in the presence of NaH in toluene. Furthermore, their nuclear imaging potentials were evaluated in human colon adenocarcinoma (HT-29) and human lung fibroblast cell (WI-38) cell lines. The uptake results have indicated that Es-SiPc labeled with I-131 radionuclide (I-131-Es-SiPc) was approximately 2-fold higher in the HT-29 cell line than the WI-38 cell line. In other words, the target/non-target tissue ratio is defined as two in the HT-29/WI-38 cell lines. Besides, the uptake values of I-131-Es-SiPc were found to be higher than I-131-Es-SiPc-2. I-131-Es-SiPc and I-131-Es-SiPc-2 are promising for imaging or treating colon adenocarcinoma. In vitrophotodynamic therapy (PDT) studies have shown that both compounds are suitable and can be used in this field. Also, Es-SiPc has been shown to have higher phototoxicity than Es-SiPc-2.