Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives

Mentese E., Yilmaz F., Karaali N., Ulker S., Kahveci B.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, cilt.40, sa.3, ss.336-342, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1134/s1068162014030091
  • Dergi Adı: RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.336-342
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by H-1 NMR and C-13 NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.