Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio May Be Used as Predictors in Febrile Seizures

Yazar A., Akin F., Ture E., Caksen H., Odabas D.

JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, vol.13, no.4, pp.283-286, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1055/s-0038-1668534
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.283-286
  • Keywords: febrile seizure, neutrophil-to-lymphocyte ratio, mean platelet volume, children, INFLAMMATION, CHILDREN, DISEASE
  • Karadeniz Technical University Affiliated: No


Febrile seizure (FS) is the most frequent seizure disorder in childhood, associated with rapid onset of high fever. Our study aims are (1) to determine if the levels of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) are risk factors for FS and to (2) assess the usefulness of these markers as predictors to distinguish the subgroups of FS. This prospective study includes children with FS, acute febrile illness (AFI) without seizure, and control group. Complete blood count was performed on all participants. The following data were obtained: white blood cell count (WBC), platelet count, MPV, hemoglobin (Hb), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and NLR. MPV, WBC, ANC, and NLR were significantly increased in patients with AFI and FS compared with controls (p < 0.05). When patients with FS and AFI were compared, only WBC was increased significantly in patients with FS (p < 0.05). WBC, ANC, and NLR were significantly increased in patients with complex FS compared with simple (p < 0.05). Our findings showed that WBC, MPV, ANC, and NLR were higher in children with FS than in the control group. Additionally WBC, ANC, and NLR were found to be higher in children with CFS than in those with simple febrile seizure. Based on the study results, we suggest that only WBC may be used as predictors in children with FS.