Akademik Veri Yönetim Sistemi
Solunum, cilt.14, sa.3, ss.169-172, 2012 (ESCI)
Adult onset Still's disease (AOSD), the adult variant of the systemic form of juvenile arthritis, is a rare systemic inflammatory disorder of unknown aetiology that is responsible for a significant proportion of cases of fever of unknown origin. The diagnosis is exclusion of infection, malignancy, and various rheumatologic disorders. Increased ferritin levels are of particular value in establishing the diagnosis. We report a case of a 55-yearold man who presented at our hospital with high fever, bilateral lower lobe infiltration seen in the chest radiography and pericardial effusion. He received therapy with broadspectrum antibiotics, but he was unresponsive to the treatment. Also, an extensive infectious serological workup was unremarkable and negative. Hepatomegaly and high fever, neutrophilic leukocytosis, and negative rheumatologic serology were consistent with AOSD. Methylprednisolone therapy was started which resulted in a remarkable clinical improvement with disappearance of the pericardial effusion and decrease in inflammatory markers. In conclusion, it is diffucult to diagnose the AOSD, and clinical suspicion with exclusion of other diagnoses is very important.