Akademik Veri Yönetim Sistemi
13th International Drug Chemistry Congress, Antalya, Türkiye, 6 - 09 Şubat 2025, ss.208, (Özet Bildiri)
The increasing prevalence of HIV-1 globally emphasizes the critical need for novel therapeutic agents capable of managing the infection while minimizing adverse effects. Current antiretroviral therapies, which target key enzymes such as reverse transcriptase (RT) and protease (PR), have demonstrated effectiveness in suppressing viral replication. However, their long-term efficacy is hindered by challenges such as toxicity and the development of drug resistance. The emergence of resistant viral strains due to genetic mutations further underscores the necessity for innovative therapeutic strategies and the identification of inhibitors with enhanced specificity and reduced adverse effects. The present research focuses on evaluating the inhibitory potential of niacin, a water-soluble molecule with extensive biological and clinical applications, against the HIV-1 reverse transcriptase (RT) enzyme through a combination of in silico and in vitro approaches. Molecular dockKng analyses revealed strong KnteractKons and sKgnKfKcant bKndKng between the 3D structure of HIV-1 RT and nKacKn. These computatKonal predKctKons were valKdated through Kn vKtro RT KnhKbKtKon assays conducted usKng the ELISA procedure, wKth the KnhKbKtory actKvKty of nKacKn compared to that of the natural HIV-1 KnhKbKtor, nevKrapKne. The fKndKngs suggest that nKacKn exhKbKts KnhKbKtory effects on HIV-1 RT, hKghlKghtKng Kts potentKal as a candKdate for further research Kn the development of therapeutKc agents targetKng HIV-1 KnfectKon.