Plasma lipoprotein (a) levels in Turkish NIDDM patients with and without vascular diabetic complications

Erem C., Deger O., Bostan M., Orem A., Sonmez M., Ulusoy Ş., ...More

Acta Cardiologica, vol.54, no.4, pp.203-207, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 1999
  • Journal Name: Acta Cardiologica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.203-207
  • Karadeniz Technical University Affiliated: Yes


Objective - Plasma concentrations of lipoprotein (a) [Lp(a)], an independent risk factor for atherosclerosis, were measured in 59 non-insulin-dependent diabetes mellitus (NIDDM) patients with and without vascular complications, and 21 non-diabetic healthy subjects. Results - The plasma log Lp(a) levels were found to be significantly increased in the NIDDM patients (1.40 ± 0.36) compared with the healthy subjects (1.02 ± 0.53; p < 0.05). Plasma Lp(a) levels in NIDDM patients with diabetic vascular complications (1.51 ± 0.27) were significantly higher than those of the NIDDM patients without diabetic vascular complications (1.23 ± 0.43) and healthy subjects (p < 0.05). There were significant correlations between plasma log Lp(a) levels and apolipoprotein B (apo B) in all NIDDM patients (r: 0.68, p < 0.05). No correlation was observed between Lp(a) levels and age, sex, duration of diabetes, fasting blood glucose, haemoglobin A1c, the mode of treatment, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoprotein AI levels in all patients. Conclusions - It was concluded that Lp(a) was a risk factor for angiopathy in NIDDM patients and the patients who have a high plasma Lp(a) concentration should be kept under strict glycaemic control.