Long-Term Effect of Chemoradiotherapy At Gastric Cancer on Pancreas

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Kandaz M., Çekiç A. B., Güler O. C., Usta M. A., Güner A., Türkyılmaz S., ...More

IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), vol.16, no.11, pp.45-51, 2017 (Peer-Reviewed Journal)


Abstract: Local or regional disease recurs or distant metastasis occur after resection in a significant proportion of those with gastric cancer.The reduce the risk of recurrence and mortality, adjuvant chemoradiotherapy has been proved to increase relapse-free survival and overall survival importantly.there is no knowledge about pancreas even it’s effected by most of the radiotherapy dose since it’s in close vicinity of stomach and dose levels which may adversely effect the pancreatic function are not defined. Therefore, the purpose of this study patients who referred to our clinic with opere gastric cancer and underwent adjuvant chemoradiotherapy were appraised prospectively and effects of pancreatic RT doses and outcomes were studied. The association among pancreatic functions, fasting blood glucose, glycosylated hemoglobin, insulin and amylase, pancreas volume and adjuvant chemoradiotherapy was determined.Before the initiation, after the first session and at the 1th, 3th, 6th, 12th and 24th months of radiotherapy, difference between serum Fasting blood glucose (p:0.209), insulin (p:0.276), HbA1c (p:0.528) and amylase levels (p:0.109) levels were not statistically significant but there is statistically significant decrease in pancreatic volume after treatment (p:0.002).Local or regional disease recurs or distant metastasis occur after surgery in a significant proportion of those with gastric cancer. Adjuvant chemoradiotherapy is able to prolong survival and decrease recurrence in operated gastric cancer patients. We could not identify any statistically significant finding related to pancreatic toxicity or its presentation on biochemical parameters except pancreas atrophy in 24 months period. Although we haven’t found any DMs in our sudy, it would be useful to continue the follow-up and perform more extensive studies. Keywords: Chemoradiotherapy, Gastric cancer, Pancreatic enzymes, Pancreas volume