Pregnancy outcome after TNF-alpha inhibitor therapy during the first trimester: a prospective multicentre cohort study

Weber-Schoendorfer C., Oppermann M., Wacker E., Bernard N., Beghin D., Cuppers-Maarschalkerweerd B., ...Daha Fazla

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, cilt.80, sa.4, ss.727-739, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/bcp.12642
  • Dergi Adı: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.727-739
  • Anahtar Kelimeler: TNF-alpha inhibitors, pregnancy outcome, birth defects, malformations, birth weight, INFLAMMATORY-BOWEL-DISEASE, NECROSIS-FACTOR INHIBITORS, CONGENITAL-ANOMALIES, RHEUMATOID-ARTHRITIS, WOMEN, SAFETY, BIRTH, ASSOCIATION, EXPOSURE, IBD
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

AimsTNF- inhibitors are considered relatively safe in pregnancy but experience is still limited. The aim of this study was to evaluate the risk of major birth defects, spontaneous abortion, preterm birth and reduced birth weight after first trimester exposure to TNF- inhibitors.