Pregnancy outcome after TNF-alpha inhibitor therapy during the first trimester: a prospective multicentre cohort study

Weber-Schoendorfer C., Oppermann M., Wacker E., Bernard N., Beghin D., Cuppers-Maarschalkerweerd B., ...More

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol.80, no.4, pp.727-739, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1111/bcp.12642
  • Journal Name: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.727-739
  • Keywords: TNF-alpha inhibitors, pregnancy outcome, birth defects, malformations, birth weight, INFLAMMATORY-BOWEL-DISEASE, NECROSIS-FACTOR INHIBITORS, CONGENITAL-ANOMALIES, RHEUMATOID-ARTHRITIS, WOMEN, SAFETY, BIRTH, ASSOCIATION, EXPOSURE, IBD
  • Karadeniz Technical University Affiliated: Yes

Abstract

AimsTNF- inhibitors are considered relatively safe in pregnancy but experience is still limited. The aim of this study was to evaluate the risk of major birth defects, spontaneous abortion, preterm birth and reduced birth weight after first trimester exposure to TNF- inhibitors.